A protein with a dual role: Both repair and mutation

Using a specialized protein, all bacteria are capable of rapidly and effectively repairing damage to their DNA from UV. However, this mutation frequency decline (Mfd) protein plays another role and causes mutations. A team1 involving scientists from CNRS, ENS-PSL and supported by Inserm has demonstrated and described this phenomenon. Better understanding of mutations opens up prospects in the fight against resistance to antibiotics and anti-cancer therapies. This study was published in PNAS on 5 April 2021.

DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis - ScienceDirect

Press area

Unravelling roles of error-prone DNA polymerases in shaping cancer genomes

DNA Damage and Repair

Chapter 12: DNA Damage and Repair - Chemistry

National Institute of Environmental Health Sciences: DNA Repair Enzymes

Frontiers R-loop Mediated DNA Damage and Impaired DNA Repair in Spinal Muscular Atrophy

Mechanisms of DNA–protein crosslink repair

DNA Damage and DNA Repair: Types and Mechanism

Repair Of Mutations - Repair Of Dna - MCAT Content