meaning - What is the definition of non-ladder or non-run

I found this word in a dictionary (my native language to English), but I cannot find it in any English one.

meaning - What is the definition of non-ladder or non-run? - English Language Learners Stack Exchange

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Whats the difference between ladder and non ladder? : r/Diablo_2_Resurrected

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Can ladder only rune word be use for non ladder character in D2R? : r/diablo2

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Can anyone explain point of ladder in D2R? : r/Diablo_2_Resurrected