Single-cell analysis of Crohn's disease reveals a detailed picture of inflammation in the gut

Researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital have constructed a high-resolution cellular map of Crohn
Researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital have constructed a high-resolution cellular map of Crohn's disease, a chronic condition in which a hyperactive immune system causes inflammation throughout the gut, leading to symptoms including abdominal pain, diarrhea, and weight loss. The disease is difficult to treat and often requires hospitalization.

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Two distinct colonic CD14+ subsets characterized by single-cell RNA profiling in Crohn's disease - Mucosal Immunology

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Science in Boston

Ramnik Xavier named as a core member of Broad Institute

IL-1-driven stromal–neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies

Xavier lab Broad Institute

Science in Boston

Early antiviral response in the nose may determine the course of